Aberrant myocardial sheetlet mobility in hypertrophic cardiomyopathy detected using in vivo cardiovascular magnetic resonance diffusion tensor imaging
نویسندگان
چکیده
Aberrant myocardial sheetlet mobility in hypertrophic cardiomyopathy detected using in vivo cardiovascular magnetic resonance diffusion tensor imaging Pedro Ferreira, Philip J Kilner, Laura-Ann McGill, Sonia Nielles-Vallespin, Andrew D Scott, Bruce S Spottiswoode, Xiaodong Zhong, Siew Y Ho, Karen McCarthy, Tevfik Ismail, Peter Gatehouse, Ranil Silva, Alexander Lyon, Sanjay K Prasad, David Firmin, Dudley J Pennell
منابع مشابه
Probing dynamic myocardial microstructure with cardiac magnetic resonance diffusion tensor imaging
This article is an invited editorial comment on the paper entitled "In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy" by Ferreira et al., and published as Journal of Cardiovascular Magnetic Resonance 2014; 16:87.
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Background Diffusion tensor imaging enables the study of cardiac microstructure in vivo, including its changes through the cardiac cycle. The left ventricle consists of myocytes with opposing helical arrangements in the epiand endocardium. Histology shows that these myocytes are arranged into small laminar “sheetlet” structures, separated by shear layers which allow the sheetlets to move and re...
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Cardiac magnetic resonance (CMR) diffusion tensor imaging (DTI) is a promising technique capable of probing the myocardial microstructure by assessing the myofiber orientation. New technical developments in CMR DTI in recent years have allowed the clinical application of this powerful imaging technique. CMR DTI has been used to study myocardial infarction and hypertrophic cardiomyopathy in pati...
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BACKGROUND Cardiac diffusion tensor imaging (cDTI) measures the magnitudes and directions of intramyocardial water diffusion. Assuming the cross-myocyte components to be constrained by the laminar microstructures of myocardium, we hypothesized that cDTI at two cardiac phases might identify any abnormalities of laminar orientation and mobility in hypertrophic cardiomyopathy (HCM). METHODS We p...
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BACKGROUND Myocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) which has been studied post-mortem, but its in-vivo prevalence and extent is unknown. Cardiac Diffusion Tensor Imaging (cDTI) provides information on mean intravoxel myocyte orientation and potentially myocardial disarray. Recent technical advances have improved in-vivo cDTI, and the aim of ...
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